
Stacks & Blends
Tesamorelin + Ipamorelin Stack
Tesamorelin + Ipamorelin Stack. Supplied as a lyophilised powder in 12mg vials.
Product information
About Tesamorelin + Ipamorelin Stack
Research background as published in the scientific literature. Supplied for in-vitro laboratory research only; nothing here is a claim about use in humans or animals.
The Tesamorelin + Ipamorelin blend combines two complementary growth hormone secretagogues that act through distinct receptor mechanisms. Tesamorelin (GHRH analogue) stimulates pituitary GH release via GHRH receptor agonism, while Ipamorelin (GHS-R1a agonist) promotes GH secretion through ghrelin receptor pathways.
The combination is researched for potential synergistic effects on GH pulsatility and the GH/IGF-1 axis. Ipamorelin's selectivity for GH secretion without cortisol or prolactin elevation makes it a preferred partner in dual-secretagogue research protocols.
- Composition
- Tesamorelin 10mg + Ipamorelin 2mg (lyophilised blend)
- Type
- Dual GH secretagogue research stack
- Research Areas
- Synergistic GH pulsatility, GH/IGF-1 axis, metabolic research
- Tesamorelin
- 10mg — GHRH receptor agonist (44 AA analogue)
- Ipamorelin
- 2mg — GHS-R1a agonist (selective GH secretagogue)
- Total Dosage
- 12mg per vial
- GH Pathway
- GHRH-R + GHS-R1a dual activation
- Half-life (CJC)
- ~30 min (Tesamorelin, research models)
- Half-life (Ipa)
- ~2 hours (Ipamorelin, research models)
- Primary Research
- GH/IGF-1 axis, metabolic effects
- 01Dual Pathway GH StimulationTesamorelin activates GHRH receptors to stimulate pituitary GH release, while Ipamorelin agonises the ghrelin receptor (GHS-R1a) via a complementary mechanism. Research examines whether co-activation of both pathways produces additive or synergistic GH pulsatility.
- 02Ipamorelin Selectivity ProfileIpamorelin is studied for its high selectivity — stimulating GH release without significantly elevating cortisol, prolactin, or ACTH. Combined with Tesamorelin, research has examined whether this selectivity profile is maintained in the blend vs. non-selective secretagogues.
- 03GH Pulsatility & IGF-1 ResearchCombined GH secretagogue protocols are investigated for their ability to restore or amplify physiological GH pulsatility. Research has examined IGF-1 response profiles, GH pulse amplitude, and frequency in animal models using this dual-pathway approach.
References
- 1Falutz J et al. Tesamorelin metabolic effects. NEJM. 2007;357(23):2359-70.
- 2Raun K et al. Ipamorelin — selective growth hormone secretagogue. Eur J Endocrinol. 1998;139:552-561.
- 3PubMed: pubmed.ncbi.nlm.nih.gov/?term=Ipamorelin+Tesamorelin
- 4PubMed: pubmed.ncbi.nlm.nih.gov/?term=Ipamorelin+GH+secretagogue
Composition
What’s inside
Supplied as a single vial. Doses are per vial, not per component vial.
- 01Tesamorelin10mg
- 02Ipamorelin2mg
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