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Quantified
Peptides
TB-500 10mg, 20mg — research peptide, lyophilised powder in a glass vial, supplied by Quantified Peptides, Sydney, Australia. For in-vitro research use only.

Peptides

TB-500

Thymosin Beta-4 Fragment (Ac-LKKTETQ), synthetic fragment of endogenous Thymosin Beta-4 protein. Supplied as a lyophilised powder in 10mg and 20mg vials.

Supplied as lyophilised powder in 10mg, 20mg specifications. Storage: -20°C · Keep dry, avoid light. Dispatched from Sydney, Australia-wide.

Product information

About TB-500

Thymosin Beta-4 Fragment (Ac-LKKTETQ)

Research background as published in the scientific literature. Supplied for in-vitro laboratory research only; nothing here is a claim about use in humans or animals.

TB-500 is a synthetic peptide fragment of Thymosin Beta-4 (Tβ4), corresponding specifically to the actin-binding domain (Ac-LKKTETQ). Thymosin Beta-4 is a ubiquitous 43-amino acid protein involved in actin sequestration and cell motility. TB-500 recapitulates key biological activities of the full protein in a shorter, more stable format.

Preclinical research has examined TB-500 in models of tendon, muscle, cardiac, and gastrointestinal tissue repair. Studies have proposed mechanisms involving actin dynamics, VEGF upregulation, inflammatory modulation, and stem cell migration. It is one of the most extensively studied tissue repair peptides in the preclinical literature.

Origin
Synthetic fragment of endogenous Thymosin Beta-4 protein
Research Areas
Actin regulation, tissue repair, angiogenesis, wound healing
Amino Acids
7 residues (Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln)
Molecular Weight
~4964 g/mol (full Tβ4)
TB-500 Sequence
Ac-LKKTETQ
Key Pathways
Actin dynamics · VEGF · Cell migration
Primary Research
Tendon, muscle, cardiac tissue repair
Research Models
Murine injury and repair models
  1. 01Actin SequestrationTB-500 corresponds to the actin-binding domain of Thymosin Beta-4. Research has examined how it sequesters G-actin monomers, influencing the dynamic equilibrium between actin polymerisation and depolymerisation — a key regulator of cell migration and tissue remodelling.
  2. 02Cell Migration & Wound HealingLaboratory studies have investigated TB-500's effects on fibroblast, keratinocyte, and endothelial cell migration in wound healing models. Research proposes that actin regulation promotes directional cell movement required for repair and re-epithelialisation.
  3. 03Angiogenesis ResearchPreclinical research has examined TB-500's role in stimulating new blood vessel formation. Studies report upregulation of VEGF and other angiogenic markers in injury models, with proposed contributions to improved perfusion of healing tissues.

References

  1. 1Goldstein AL et al. Thymosin beta4: actin-sequestering protein. Ann N Y Acad Sci. 2005;1112:171-180.
  2. 2Bock-Marquette I et al. Thymosin beta4 activates integrin-linked kinase for cardiac repair. Nature. 2004;432:466-472.
  3. 3PubMed: pubmed.ncbi.nlm.nih.gov/?term=TB-500+thymosin+beta4
  4. 4Smart N et al. Thymosin beta4 induces cardiac stem cell differentiation. Nature. 2007.

Ships from Sydney

Australia-wide, plain unbranded packaging. Dispatched on business days.

If it arrives wrong

Replaced, resent or refunded. You do not have to argue for it.

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