SLU-PP-332

SLU-PP-332 is a synthetic compound developed by researchers at Saint Louis University as a pan-agonist of the Estrogen Related Receptor family (ERRα, ERRβ, ERRγ). ERRs are orphan nuclear receptors that regulate networks of genes involved in mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation.

Preclinical research has investigated SLU-PP-332 as a potential exercise mimetic, with rodent studies reporting activation of molecular pathways associated with endurance adaptations. The compound represents a research tool for studying ERR biology and mitochondrial metabolic regulation.

Type

Synthetic small molecule / ERR pan-agonist

Research Areas

Mitochondrial biogenesis, oxidative metabolism, exercise mimetics

Molecular Formula

C23H22N2O3

Molecular Weight

378.4 g/mol

Developer

Saint Louis University research group

Key Pathways

ERRα/γ · PGC-1α · Mitochondrial biogenesis

Primary Research

Oxidative metabolism, exercise mimetics

Research Models

Rodent metabolic and endurance models

1. 01ERRα / ERRγ Pan-AgonismSLU-PP-332 was developed as a pan-agonist of the Estrogen Related Receptors α, β, and γ. Research examines its binding affinity and transcriptional activation across ERR subtypes, which regulate mitochondrial biogenesis and oxidative metabolism gene networks.
2. 02Mitochondrial BiogenesisLaboratory studies have investigated SLU-PP-332's effects on PGC-1α co-activation and downstream mitochondrial gene expression. Animal studies report increases in mitochondrial density and oxidative capacity in skeletal and cardiac muscle tissue models.
3. 03Exercise Mimetic PathwaysResearch has examined whether SLU-PP-332 can activate metabolic adaptations typically associated with endurance exercise at the molecular level. Studies in rodent models have reported improvements in running performance and metabolic markers without training.