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5-Amino-1MQ 50mg — research peptide, lyophilised powder in a glass vial, supplied by Quantified Peptides, Sydney, Australia. For in-vitro research use only.

Peptides

5-Amino-1MQ

5-Amino-1-methylquinolinium. Supplied as a lyophilised powder in 50mg vials.

Supplied as lyophilised powder in a 50mg specification. Storage: -20°C · Keep dry, avoid light. Dispatched from Sydney, Australia-wide.

Product information

About 5-Amino-1MQ

5-Amino-1-methylquinolinium

Research background as published in the scientific literature. Supplied for in-vitro laboratory research only; nothing here is a claim about use in humans or animals.

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule inhibitor of Nicotinamide N-methyltransferase (NNMT), an enzyme that catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide. Elevated NNMT activity has been associated with adipogenesis and metabolic dysfunction in research models.

Research has examined 5-Amino-1MQ's ability to reduce NNMT activity in adipose tissue, with studies reporting effects on fat cell differentiation, SAM levels, and body composition parameters in preclinical models. Its role in NAD+ precursor salvage pathways makes it of interest in the context of metabolic and longevity research.

Type
Small molecule NNMT inhibitor
Research Areas
Adipogenesis, metabolic regulation, NAD+ pathways
Target Enzyme
Nicotinamide N-methyltransferase (NNMT)
Molecular Weight
~174 Da
Research Area
Adipogenesis, metabolic disease
Key Pathway
SAM methylation · NAD+ metabolism
Tissue Target
White adipose tissue
Research Models
Murine adipocyte models
  1. 01NNMT Inhibition5-Amino-1MQ is studied as an inhibitor of Nicotinamide N-methyltransferase (NNMT), an enzyme involved in epigenetic regulation and methyl group metabolism. Research examines how NNMT inhibition affects adipocyte differentiation.
  2. 02NAD+ & SAM PathwaysBy inhibiting NNMT, 5-Amino-1MQ may increase cellular SAM (S-adenosylmethionine) availability and influence NAD+ precursor pools. Research investigates downstream effects on methylation reactions and energy metabolism.
  3. 03Adipocyte BiologyLaboratory studies have examined 5-Amino-1MQ's effects on white adipose tissue differentiation and lipid accumulation, with research proposing roles in metabolic adaptation and fat cell energy expenditure.

References

  1. 1Neelakantan H et al. Selective and membrane-permeable small molecule inhibitors of NNMT. Biochemistry. 2017;56(5):806-821.
  2. 2Hong S et al. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015;21:887-894.
  3. 3PubMed: pubmed.ncbi.nlm.nih.gov/?term=5-amino-1MQ+NNMT
  4. 4Kraus D et al. NNMT inhibition reverses features of white adipose tissue browning. Cell Metab. 2014;19(6):1019-1027.

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