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Peptides
Pinealon 20mg — research peptide, lyophilised powder in a glass vial, supplied by Quantified Peptides, Sydney, Australia. For in-vitro research use only.

Peptides

Pinealon

EDR Peptide / Glu-Asp-Arg, derived from Cortexin (bovine brain extract). Supplied as a lyophilised powder in 20mg vials.

Supplied as lyophilised powder in a 20mg specification. Storage: -20°C · Keep dry, avoid light. Dispatched from Sydney, Australia-wide.

Product information

About Pinealon

EDR Peptide / Glu-Asp-Arg

Research background as published in the scientific literature. Supplied for in-vitro laboratory research only; nothing here is a claim about use in humans or animals.

Pinealon (EDR) is a synthetic tripeptide (Glu-Asp-Arg) classified as a peptide bioregulator, originally isolated from Cortexin — a polypeptide complex derived from bovine brain tissue. It is one of Khavinson's peptides, a class of ultra-short bioregulators studied extensively in Russian gerontology research.

Research has focused on Pinealon's neuroprotective properties, its ability to cross the blood-brain barrier, and its effects on cognitive function in aging and neurodegeneration models. Studies have also examined its potential role in circadian rhythm regulation via the pineal gland.

Origin
Derived from Cortexin (bovine brain extract)
Research Areas
Neuroprotection, cognitive aging, CNS gene regulation
Amino Acids
3 residues (Glu-Asp-Arg)
Molecular Formula
C15H26N6O8
Molecular Weight
418.4 g/mol
Classification
Khavinson peptide bioregulator
Key Pathways
MAPK/ERK · DNA interaction · Serotonin
Primary Research
Neuroprotection, cognitive aging
Research Models
HeLa cells, aged rodent models
  1. 01Direct DNA InteractionUnlike most peptides, Pinealon is proposed to penetrate cellular and nuclear membranes to interact directly with DNA. Research in HeLa cell cultures suggests it may bind to specific promoter sequences to regulate gene expression in neural tissues.
  2. 02MAPK/ERK Pathway ModulationStudies propose that Pinealon may attenuate MAPK and ERK signalling by reducing reactive oxygen species (ROS) levels. This attenuation may reduce cellular stress and inhibit apoptosis in neuronal models.
  3. 03Serotonin Pathway ResearchCell culture studies have suggested that Pinealon may stimulate serotonin expression — with one study reporting increases of 1.9x in younger cell cultures — potentially via binding to the promoter region of the 5-tryptophan hydroxylase gene.

References

  1. 1Khavinson VK et al. Peptide pinealon regulates neuronal cell functions. Neuro Endocrinol Lett. 2002. PMID:12500167
  2. 2Trofimova SV et al. Pinealon reduces oxidative stress in rats. Adv Gerontol. 2010. PMID:20684159
  3. 3PubMed: pubmed.ncbi.nlm.nih.gov/?term=Pinealon+neuroprotection
  4. 4Wikipedia: Pinealon — en.wikipedia.org/wiki/Pinealon

Ships from Sydney

Australia-wide, plain unbranded packaging. Dispatched on business days.

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Replaced, resent or refunded. You do not have to argue for it.

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