KPV

KPV (Lys-Pro-Val) is a tripeptide representing the C-terminal amino acids 11-13 of alpha-melanocyte-stimulating hormone (alpha-MSH). Research has demonstrated that this short fragment retains significant anti-inflammatory activity relative to the full alpha-MSH peptide.

Studies have investigated KPV's ability to activate melanocortin receptors and modulate NF-kB-driven inflammatory cascades. Research interest has focused on gut inflammation models, with studies examining KPV's effects on intestinal epithelial barrier function and colitis biomarkers in preclinical models.

Type

Tripeptide — alpha-MSH derivative

Research Areas

Anti-inflammatory, gut health, wound healing

Sequence

Lys-Pro-Val

Origin

C-terminal fragment of alpha-MSH (11-13)

Molecular Weight

~340 Da

Target

MC1R, MC3R

Primary Research

Inflammatory bowel disease models

Key Pathway

NF-kB inhibition via MCR signalling

Research Models

Intestinal epithelial · skin wound

1. 01MC1R Anti-Inflammatory SignallingKPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (alpha-MSH). Research has examined its ability to activate melanocortin receptors (MC1R, MC3R) to modulate NF-kB signalling and pro-inflammatory cytokine production.
2. 02Gut Mucosal ProtectionLaboratory studies have investigated KPV's effects on intestinal epithelial cell models, with research examining effects on tight junction protein expression, intestinal permeability, and inflammatory cytokine secretion in colitis models.
3. 03Wound HealingResearch has explored KPV's influence on wound healing parameters including fibroblast migration, collagen synthesis, and anti-inflammatory cytokine profiles in skin wound models, proposing roles in resolving inflammatory wound phases.