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Kisspeptin 5mg — research peptide, lyophilised powder in a glass vial, supplied by Quantified Peptides, Sydney, Australia. For in-vitro research use only.

Peptides

Kisspeptin

Kisspeptin (Metastin). Supplied as a lyophilised powder in 5mg vials.

Supplied as lyophilised powder in a 5mg specification. Storage: -20°C · Keep dry, avoid light. Dispatched from Sydney, Australia-wide.

Product information

About Kisspeptin

Kisspeptin (Metastin)

Research background as published in the scientific literature. Supplied for in-vitro laboratory research only; nothing here is a claim about use in humans or animals.

Kisspeptin is a neuropeptide encoded by the KISS1 gene, originally discovered as a metastasis suppressor gene product (hence also known as Metastin). Its role in reproductive neuroendocrinology was elucidated when KISS1R loss-of-function mutations were found to cause hypogonadotropic hypogonadism.

Research has established kisspeptin as a critical upstream regulator of GnRH pulsatility, with studies examining kisspeptin neuron populations in the hypothalamus and their roles in puberty, fertility, and reproduction. Kisspeptin-54 (the longest active form) and shorter fragments including kisspeptin-10 have been studied in clinical research protocols examining GnRH and gonadotropin secretion in humans.

Type
Neuropeptide — KISS1 gene product
Research Areas
GnRH regulation, puberty, reproductive axis
Gene
KISS1 (chromosome 1q32)
Active Forms
Kp-54, Kp-14, Kp-13, Kp-10
Target
KISS1R (GPR54)
Molecular Weight
~6.5 kDa (Kp-54)
Primary Function
GnRH pulse regulation
HPG Axis
Hypothalamus → pituitary → gonads
Clinical Research
Hypogonadism, IVF protocols
  1. 01GnRH Pulse GenerationKisspeptin acts on the KISS1R receptor on GnRH neurons to stimulate pulsatile gonadotropin-releasing hormone (GnRH) secretion. Research examines its role as a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis.
  2. 02HPG Axis ResearchLaboratory and clinical research has investigated kisspeptin's role in triggering pubertal onset, regulating the menstrual cycle, and modulating fertility. Studies have examined kisspeptin neuron populations in the hypothalamic arcuate and anteroventral periventricular nuclei.
  3. 03Reproductive EndocrinologyResearch has examined kisspeptin's diagnostic and research applications in studying reproductive disorders including hypothalamic amenorrhoea, hypogonadotropic hypogonadism, and polycystic ovary syndrome in both animal and human research models.

References

  1. 1Seminara SB et al. The GPR54 gene as a regulator of puberty. NEJM. 2003;349(17):1614-1627.
  2. 2Dhillo WS et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-6615.
  3. 3PubMed: pubmed.ncbi.nlm.nih.gov/?term=kisspeptin+GnRH
  4. 4Oakley AE et al. Kisspeptin signaling in the brain. Endocr Rev. 2009;30(6):713-743.

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