DSIP

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (9 amino acids) first isolated from rabbit brain by Monnier et al. in 1977. It was identified during studies of cerebral perfusate from rabbits during electrically induced slow-wave sleep.

Research has examined its effects on sleep architecture, neuroendocrine signalling, and stress responses. Studies have proposed roles in modulating multiple hormone systems and normalising disrupted sleep-wake cycles in animal models. Its precise mechanisms and receptor targets remain subjects of ongoing investigation in neuropeptide research.

Type

Naturally occurring neuropeptide

Research Areas

Sleep architecture, neuroendocrine regulation, stress response

Amino Acids

9 residues (nonapeptide)

CAS Number

62568-57-4

Molecular Weight

849 Da

Discovery

Monnier et al., 1977

Primary Research

Sleep induction, EEG delta waves

Hormones Studied

GH, LH, ACTH, TSH

Species Studied

Rabbit, rat, human (limited)

1. 01Sleep ArchitectureDSIP was originally isolated by Monnier et al. for its purported ability to induce delta (slow-wave) sleep patterns. Research has examined its effects on sleep stage duration and EEG delta wave activity in animal and human models.
2. 02Neuroendocrine ModulationLaboratory research has investigated DSIP's effects on multiple hormone systems, including GH, LH, corticotropin, and thyroid hormone, with studies examining its role as a potential neuroendocrine modulator.
3. 03Stress ResponseResearch has examined DSIP's effects on stress-induced hormone release and behavioural responses in animal models, with studies proposing roles in normalising disturbed endocrine rhythms under stress conditions.