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Dihexa 10mg — research peptide, lyophilised powder in a glass vial, supplied by Quantified Peptides, Sydney, Australia. For in-vitro research use only.

Peptides

Dihexa

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, angiotensin IV derivative. Supplied as a lyophilised powder in 10mg vials.

Supplied as lyophilised powder in a 10mg specification. Storage: -20°C · Keep dry, avoid light. Dispatched from Sydney, Australia-wide.

Product information

About Dihexa

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

Research background as published in the scientific literature. Supplied for in-vitro laboratory research only; nothing here is a claim about use in humans or animals.

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a short peptide derived from angiotensin IV that acts as a potentiator of HGF/MET signalling. It was developed at Washington State University as a potential cognitive enhancer based on its angiotensin IV binding properties.

Research has examined its potency relative to brain-derived neurotrophic factor (BDNF) in some assays, with studies investigating effects on synapse formation, neural plasticity, and cognitive performance in aged and cognitively impaired animal models. It represents an area of active preclinical investigation in the nootropic peptide field.

Type
HGF/MET receptor modulator
Research Areas
Cognitive function, synaptic plasticity, neurogenesis
Origin
Angiotensin IV derivative
Target
HGF/MET receptor potentiator
Molecular Weight
~495 Da
Institution
Washington State University
Key Effect
Enhanced synaptogenesis
Research Models
Hippocampal · aged animal
Compared To
~7x more potent than BDNF (in vitro)
  1. 01HGF/MET SignallingDihexa acts as a potentiator of HGF (hepatocyte growth factor) binding to the MET receptor tyrosine kinase. Research examines downstream effects on neuronal survival, axonal growth, and synaptic density in cognitive research models.
  2. 02SynaptogenesisLaboratory studies have examined Dihexa's effects on dendritic spine density and synapse formation in hippocampal models. Research proposes roles in enhancing synaptic connectivity relevant to memory consolidation research.
  3. 03Cognitive Research ModelsPreclinical studies have examined Dihexa's effects in aged animal models and models of cognitive decline, with studies reporting effects on spatial learning and memory task performance.

References

  1. 1McCoy AT et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2013;344(1):141-154.
  2. 2Benoist CC et al. Facilitation of hippocampal synaptogenesis and spatial memory by dihexa. J Pharmacol Exp Ther. 2011;336(2):452-464.
  3. 3PubMed: pubmed.ncbi.nlm.nih.gov/?term=Dihexa+peptide
  4. 4Wright JW et al. Angiotensin IV and its analogs: potential therapeutic agents for treating dementia. J Renin Angiotensin Aldosterone Syst. 2010;11(3):145-151.

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