$90
Peptides
LL-37
LL-37 (human cathelicidin antimicrobial peptide), c-terminal of hCAP-18. Supplied as a lyophilised powder in 5mg vials.
Supplied as lyophilised powder in a 5mg specification. Storage: -20°C · Keep dry, avoid light. Dispatched from Sydney, Australia-wide.
Product information
About LL-37
LL-37 (human cathelicidin antimicrobial peptide)
Research background as published in the scientific literature. Supplied for in-vitro laboratory research only; nothing here is a claim about use in humans or animals.
LL-37 is the only known human cathelicidin, derived from the C-terminal cleavage of hCAP-18 (human cationic antimicrobial protein of 18 kDa) by serine proteases. It is stored in neutrophil granules and produced in epithelial cells of the skin, respiratory and gastrointestinal tracts.
Research has examined LL-37's multifunctional roles in innate immunity, with studies demonstrating both direct antimicrobial properties and immunomodulatory effects on multiple cell types. Its expression is regulated by vitamin D and has been investigated in research contexts including skin infections, lung inflammation, and cancer biology.
- Type
- Cathelicidin — endogenous host defence peptide
- Research Areas
- Antimicrobial, immunomodulation, wound healing
- Amino Acids
- 37 residues (cationic)
- Origin
- C-terminal of hCAP-18
- Molecular Weight
- ~4.5 kDa
- CAS Number
- 154947-66-7
- Structure
- Alpha-helical amphipathic peptide
- Sources
- Neutrophils, epithelial cells, skin
- 01Antimicrobial ActivityLL-37 is a 37-amino acid cationic peptide with broad-spectrum antimicrobial activity. Research has examined its ability to disrupt bacterial, fungal, and viral membranes through electrostatic interactions with negatively charged lipopolysaccharide components.
- 02ImmunomodulationBeyond direct antimicrobial effects, LL-37 research has examined its role as an immunomodulator. Studies investigate its effects on macrophage activation, dendritic cell differentiation, chemokine receptor expression, and Toll-like receptor signalling.
- 03Wound Healing & AngiogenesisResearch has investigated LL-37's roles in wound healing, with studies examining its ability to stimulate epithelial cell migration, angiogenesis via VEGF pathways, and anti-biofilm activity in wound infection models.
References
- 1Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol. 2004;75(1):39-48.
- 2Mookherjee N et al. Modulation of the TLR-mediated inflammatory response by the endogenous human host defence peptide LL-37. J Immunol. 2006;176(4):2455-2464.
- 3PubMed: pubmed.ncbi.nlm.nih.gov/?term=LL-37+cathelicidin
- 4Tokumaru S et al. Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37. J Immunol. 2005;175(7):4662-4668.
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